Also known as blood
cancer leukemia, leukemia is divided into acute and chronic, acute myelogenous
leukemia, and further divided into lymphocytic. Acute
myeloid leukemia according to their shape into eight types of blood cells,
wherein the third type of blood cells, more mature than other types, and are
"promyelocytic ball" phase, so called "ball acute promyelocytic leukemia."
Because
this disease before malignant proliferation of myeloid ball, and promyelocytic
ball quickly rupture, its intracellular substances can cause large changes in
consumption of large quantities of blood coagulation factors and platelets.
Because leukemia
stronghold in the bone marrow, and bone marrow where blood cells are
manufactured, further platelet deficiency. Therefore, patients often die soon because of massive
bleeding. The
blood cells have a special fifteenth and seventeenth chromosome translocation,
the translocation is precisely the product will be accepted fully
indexable-retinoic acid (tretinoin short) into the blood cells, and makes the
blood cell differentiation, maturation, but does not rupture the cells, thereby greatly
reducing deaths due to massive bleeding. This "repented" effect, and the traditional
anti-cancer chemotherapy is completely different. However, for other types of leukemia retinoic
acid and malignant tumors, but no effect.
This oral retinoids ball past decade in the acute promyelocytic leukemia treatment caused a revolutionary impact. After extensive trials in Europe and America and other countries, so that the treatment of this disease is more advanced. Treatment in three stages. First, you must make a significant reduction in blood cells, bone marrow and restore near-normal morphology and function, known as "mitigation." In the past, only chemotherapy, the patients often die of bleeding. If only retinoic acid, are generally required to achieve remission more than a month, while the number of white blood cells early treatment, but often so rapidly increased, sometimes fatal. If the combination of retinoic acid and the beginning of chemotherapy, the same as to reduce bleeding, and is faster and more smoothly to achieve remission. Response rate can be up to 90 percent, compared with chemotherapy alone or retinoic acid are much higher. Chemical drugs as "cranberries" (because the liquid was dark red), the most effective. Achieve remission, and then to chemotherapy to "reinforce" the disease, is still "cranberries" category mainly injected approximately every four weeks a few days, a total of three rounds. Followed by "maintenance period" oral retinoids and other drugs. Recent Western advocates eating fifteen days every three months, a new approach retinoic acid. Treatment, a few patients will relapse due to complications or because of death. Currently the best cure rate of eighty percent, better than bone marrow transplantation. This disease than any other type of blood cancer "altogether" less likely to relapse if treatment starts after the expiry of two to three years, there is still no relapse, you can say "cure" it.
The author in 1995. Has presided over a major medical center co-retinoic acid clinical treatment programs in the country to start using the best retinoic acid preparations. Hematology and Oncology, Chang Gung Memorial Hospital, using the preceding six years, the most progressive therapy, the cure rate was as high as 80%, comparable with other advanced countries worldwide. Future undergraduate medical team will continue its efforts to make the treatment of this disease in Taiwan to upgrade the level of energy.
This oral retinoids ball past decade in the acute promyelocytic leukemia treatment caused a revolutionary impact. After extensive trials in Europe and America and other countries, so that the treatment of this disease is more advanced. Treatment in three stages. First, you must make a significant reduction in blood cells, bone marrow and restore near-normal morphology and function, known as "mitigation." In the past, only chemotherapy, the patients often die of bleeding. If only retinoic acid, are generally required to achieve remission more than a month, while the number of white blood cells early treatment, but often so rapidly increased, sometimes fatal. If the combination of retinoic acid and the beginning of chemotherapy, the same as to reduce bleeding, and is faster and more smoothly to achieve remission. Response rate can be up to 90 percent, compared with chemotherapy alone or retinoic acid are much higher. Chemical drugs as "cranberries" (because the liquid was dark red), the most effective. Achieve remission, and then to chemotherapy to "reinforce" the disease, is still "cranberries" category mainly injected approximately every four weeks a few days, a total of three rounds. Followed by "maintenance period" oral retinoids and other drugs. Recent Western advocates eating fifteen days every three months, a new approach retinoic acid. Treatment, a few patients will relapse due to complications or because of death. Currently the best cure rate of eighty percent, better than bone marrow transplantation. This disease than any other type of blood cancer "altogether" less likely to relapse if treatment starts after the expiry of two to three years, there is still no relapse, you can say "cure" it.
The author in 1995. Has presided over a major medical center co-retinoic acid clinical treatment programs in the country to start using the best retinoic acid preparations. Hematology and Oncology, Chang Gung Memorial Hospital, using the preceding six years, the most progressive therapy, the cure rate was as high as 80%, comparable with other advanced countries worldwide. Future undergraduate medical team will continue its efforts to make the treatment of this disease in Taiwan to upgrade the level of energy.
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